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Summary Statistics

You can filter the data below or go straight to the results. Descriptions of the various cell types we distribute, such as CPLs and LCLs, can be found here. Information on ordering biomaterials can be found here.

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Disease Distributions

Subjects are grouped into distributions according to the way they were ascertained for their respective studies. This should not be confused with clinical diagnoses. Subjects in the Nicotine Dependence distribution, for example, may or may not be diagnosed with Nicotine Dependence. By default, all distributions are used.

Clinical Diagnoses

The definition of "Affected" depends on the study. The definition for the primary phenotype of each study is shown in the study breakdown section below unless hidden via the option above.

Dependence

Alcohol Dependence:

Cannabis Dependence:

Cocaine Dependence:

Nicotine Dependence:

Opioid Dependence:

Sedative Dependence:

Stimulant Dependence:

Other Dependence:

Abuse

Alcohol Abuse:

Cannabis Abuse:

Cocaine Abuse:

Opioid Abuse:

Sedative Abuse:

Stimulant Abuse:

Other Abuse:

Multiple Diagnosis Logic*: OR AND

*Example: when OR is selected, if you select both Nicotine and Alcohol dependence you get statistics for the combined set Nicotine-dependent subjects and Alcohol-dependent subjects. When AND is selected, you get statistics for subjects that are both Nicotine-dependent and Alcohol-dependent.

Demographics, Biomaterials and Clinical Instruments

Sex:

Age:Between and

Self-Identified Race/Ethnicity:

Has DNA:

Cell Types:

Cell Types Logic: OR AND

Cell type descriptions can be found here.

Clinical Instrument(s):

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Results

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Breakdown by Disease Distribution

Cell type descriptions (LCLs, CPLs, etc) can be found here.

Distribution Subjects With DNA Plasma LCLs CPLs Whole Blood
Polysubstance Dependence 4,453 3,465 (78%) 3 ( 0%) 2,004 (45%) 3,365 (76%) 1,814 (41%)
Total 4,453 3,465 (78%) 3 ( 0%) 2,004 (45%) 3,365 (76%) 1,814 (41%)

Demographics, DNA and Clinical Instruments

Item Value
Subjects 4,453
With DNA 3,465 (78%)
Instrument: DSM-IV 2,214 (50%)
Instrument: DSM-III-R 891 (20%)
Instrument: Unknown 1,348 (30%)
Females / Males / Unknown 1,890 (42%) / 2,563 (58%) / 0 (0%)
Age Average: 28.4, Min: 11, Max: 72

Self-Identified Race/Ethnicity

Race/Ethnicity Subjects
White Non-Hispanic 2,652 (60%)
Other 998 (22%)
African-American 522 (12%)
White Hispanic 274 ( 6%)
Asian 5 ( 0%)
American Indian 2 ( 0%)

Cell Types

Cell type descriptions (LCLs, CPLs, etc) can be found here.

Cell Type Subjects
LCL 2,004 (45%)
CPL 3,365 (76%)
LCL gDNA 1,927 (43%)
WB gDNA 1,958 (44%)
Plasma 3 ( 0%)
Whole Blood 1,814 (41%)

Diagnoses

Disease Affected* Unaffected Other
Alcohol Dependence 1,001 (22%) 1,917 (43%) 1,535 (34%)
Cannabis Dependence 1,043 (23%) 1,831 (41%) 1,579 (35%)
Cocaine Dependence 284 ( 6%) 2,766 (62%) 1,403 (32%)
Nicotine Dependence 746 (17%) 1,473 (33%) 2,234 (50%)
Opioid Dependence 176 ( 4%) 2,342 (53%) 1,935 (43%)
Other Drug Dependence 160 ( 4%) 2,945 (66%) 1,348 (30%)
Sedative Dependence 51 ( 1%) 2,477 (56%) 1,925 (43%)
Stimulant Dependence 214 ( 5%) 2,838 (64%) 1,401 (31%)
Alcohol Abuse 605 (14%) 1,152 (26%) 2,696 (61%)
Cannabis Abuse 468 (11%) 1,273 (29%) 2,712 (61%)
Cocaine Abuse 92 ( 2%) 2,039 (46%) 2,322 (52%)
Opioid Abuse 72 ( 2%) 1,582 (36%) 2,799 (63%)
Other Drug Abuse 150 ( 3%) 2,069 (46%) 2,234 (50%)
Sedative Abuse 44 ( 1%) 1,615 (36%) 2,794 (63%)
Stimulant Abuse 73 ( 2%) 2,003 (45%) 2,377 (53%)

*The definition of affected depends on the study and is shown in the study breakdown below (unless hidden via the option above).

Breakdown by NIDA Studies

Cell type descriptions (LCLs, CPLs, etc) can be found here. The "Definition of Affected" refers to the primary phenotype of the study.

Polysubstance Dependence
Study Name PI Definition of Affected N With DNA Plasma LCLs CPLs Whole Blood
11 Adolescent Drug Dependence John Hewitt DSM Opioid, Cocaine, Cannabis, Stimulant, Sedative, or other dependence 2,403 1,589 (66%) 1 ( 0%) 1,084 (45%) 1,521 (63%) 502 (21%)
12 Substance Abuse and the Dopamine System Genes Michael M. Yanyukov DSM Opioid, Cocaine, Cannabis, Stimulant, Sedative, or other dependence 600 470 (78%) 0 ( 0%) 406 (68%) 449 (75%) 0 ( 0%)
19 Epidemiological Study of Substance Abuse Rob Philibert DSM Opioid, Cocaine, Cannabis, Stimulant, Sedative, or other dependence 562 520 (93%) 1 ( 0%) 485 (86%) 510 (91%) 430 (77%)
23 Substance Use Disorder Liability: Candidate Gene System Michael M. Vanyukov DSM Opioid, Cocaine, Cannabis, Stimulant, Sedative, or other dependence 888 886 (100%) 1 ( 0%) 29 ( 3%) 885 (100%) 882 (99%)
Total 4,453 3,465 (78%) 3 ( 0%) 2,004 (45%) 3,365 (76%) 1,814 (41%)

cell_file version: 2023-11-14 #2